Germany in the 1920s. Martha Dehnert is a petite young girl nicknamed Krümel and grows up in a working-class family in Potsdam. Despite difficult times, she is passionate about her ideals.

Three best friends, Inken, Vicky, and Lena, each have a mind of their own, but they share the same goal: to finally have their first orgasm! But it’s not that easy: amid rivalries, languishing crushes, intimate secrets, and a yeast infection, the girls face many obstacles that will put their friendship to the test.

A wild, eight-year-old girl is puzzling the Thai authorities. She was picked up in a town on the edge of the rainforest. The chief of police asks the renowned German child psychologist Dr. Julia Wagner, who works in an international private clinic in Bangkok, for help. She touchingly takes care of the child. When everything seems to be going well, the girl's father comes into the picture: Has he been wrongly accused of kidnapping his wife and child?

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Irka and Raya are best friends, one always knows immediately what the other wants. Irka is young, lively and a girl, Raya is old, blind and a proud mare who had great times as a show horse. The two are inseparable. But when Raya has a foal, Irka turns her attention to the small, helpless and cute animal. Her father had actually promised that she could keep both horses. One day, however, he tells her that she has to part with one of the horses. Irka has to decide for herself: The cute foal or the old mare?

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Mila (Emilia Schüle), Hanna (Selina Shirin Müller) und Kati (Henriette Nagel) sind beste Freundinnen. Sie treffen sich meistens im Friseursalon von Milas Mutter (Anke Engelke), einer charmanten, aber chaotischen Friseuse. In der Schule haben sie es mit einem speziellen Lehrerkollegium zu tun, einem überzeugten Mathematiklehrer (Armin Rohde), einem in die Deutschlehrerin verliebten Musiklehrer und einem Referendar, der viel zu jung aussieht. Hanna und Kati haben gerade ihre ersten Beziehungen, die hauptsächlich aus SMS-en, knutschen und Händchenhalten bestehen.